Clostridium: Transmission difficile?
نویسندگان
چکیده
Clostridium difficile can cause large-scale outbreaks of diarrhea [1,2]. Significant progress has recently been achieved to improve treatment of symptomatic C. difficile disease [3]. But hospitals affected by C. difficile infection still face challenges in the effort to control endemic C. difficile infections, which may be related to overuse of antibiotics (e.g., fluoroquinolones, cephalosporins), problems in cleaning services, and poor isolation practices [4,5]. Furthermore, current diagnostic tests for C. difficile are not sensitive enough [6] and diagnosis can be delayed [7]. Evidence for the rate of nosocomial acquisition of C. difficile and the likelihood of within-hospital transmission from patients to patients of C. difficile infection remains scarce, so an improved evidence base could help improve infection control strategies [8]. Only a few studies have examined in detail the prevalence of C. difficile in hospital patients upon admission and nosocomial transmission rates of C. difficile infection [9]. For instance, 15 years ago, Samore et al. reported that for most epidemiologically linked contacts of C. difficile cases, positive cultures for C. difficile did not result from transmission from the presumed index case [8]. However, this and other studies were conducted before the emergence of new hypervirulent C. difficile strains and might not reflect the current epidemiology of C. difficile transmission.
منابع مشابه
Molecular Analysis of Toxigenic Clostridium difficile Isolates from Hospital Environment by PCR Ribotyping Method
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